The result of the variant on RNA or protein functionality, dependant on experimental evidence from submitters.
This price is calculated by NCBI depending on details from submitters. Examine our principles for calculating the critique status. The volume of submissions which contribute to this evaluation position is proven in parentheses.
This day represents the last time this VCV document was up to date. The update may very well be on account of an update to one of the incorporated submitted information (SCVs), or resulting from an update that ClinVar produced into the variant like including HGVS expressions or possibly a rs amount.
This column involves more info supporting the classification, which include citations, the comment on classification, and detailed evidence provided as observations with the variant with the submitter.
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The mixture germline classification for this variant, typically for the monogenic or Mendelian ailment as in the ACMG/AMP recommendations, or for response to some drug. This worth is calculated by NCBI determined by details from submitters. Go through our regulations for calculating the aggregate classification.
There aren't any citations for germline classification of the variant in ClinVar. If you recognize of citations for this variation, remember to take into account distributing that data to ClinVar.
The publishing Business for this submitted (SCV) history. This column also involves the SCV accession and version range, the date this SCV initially appeared in ClinVar, as well as the day this SCV was previous current in ClinVar.
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Stars characterize the mixture review position, or the level of review supporting the mixture germline classification for this VCV file.
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The website is protected. The https:// makes certain that you're connecting to the Formal Web site Which any data you present is encrypted and transmitted securely.
Stars depict the overview standing, or the level of evaluation supporting the submitted (SCV) document. This value is calculated by NCBI based on details within the submitter.